LC3-mHTT-IN-AN1 ( —— )

产品货号. M21755 CAS No. 486443-73-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

LC3-mHTT-IN-AN1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
产品描述

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
同义词

——
通路

Autophagy
靶点

Autophagy
受体

——
研究领域

——
适应症

——

CAS Number

486443-73-6
分子量

411.04
分子式

C15H9Br2NO3
纯度

>98% (HPLC)
溶解度

DMSO : 125 mg/mL (304.11 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)
SMILES

BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
化学全称

——

1. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.

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